A major study conducted at the Sahlgrenska Academy has now disproved theories of a viral cause for breast cancer and the brain tumour, glioblastoma. The study, which was based on over seven billion DNA sequences and which is published in Nature Communications, found no genetic traces of viruses in these forms of cancer.
It has been scientifically proven that about 15 per cent of all cancer
cases are the result of viral infection, but many researchers believe
that even more cancers could be caused by viruses. Among other theories,
it is suggested that the Epstein-Barr virus could be a possible cause
of breast cancer and that the cytomegalovirus might cause the malignant brain tumour glioblastoma.
"There is some controversy in that we have not found any viruses in
these forms of cancer, but if there were any viral involvement in breast
cancer and glioblastoma, it is likely that we would have found some
trace of it. We have based our research on American material, which is
extremely comprehensive," says Erik Larsson, who is a researcher at the
Sahlgrenska Academy at the University of Gothenburg.
The study was published in the highly-regarded scientific journal Nature
Communications. The study involved the researchers using powerful
computers to conduct in-depth analysis of 700 billion DNA sequences from
more than 4,000 tumours.
"We conducted an unbiased search for viruses in 19 different types of
cancer. The analysis has neatly confirmed the links that are already
known, which effectively confirms that we are using the right method,"
says Erik Larsson.
The result of the study is a massive chart of viral presence in cancer. Among other things, the study was able to confirm that liver cancer is often caused by the hepatitis
virus, and that the human papilloma virus causes cervical cancer. The
study also shows that viral infection also causes major adaptations in
the tumour cell, and that virus-positive tumours from widely different
organs can therefore display considerable similarities.
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